If a gas not containing any oxygen is breathed, consciousness is rapidly lost with no increase whatever in the rate of breathing. Haldane had witnessed the effects first-hand down in the coal mines of South Wales: “Thus it is a common experience with miners going into an atmosphere of nearly pure fire damp [methane, CH4], or climbing up so that their heads are in the gas; they drop suddenly as if they were shot.” The response to rapidly halving the oxygen level breathed is actually an increase in pulse rate and blood flow, not an increase in the rate of breathing. The increase in pulse rate had first been recorded by Glaisher and Coxwell in their epic ascent from Wolverhampton gas works; it had risen from 70 on the ground to 100 at altitude.
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